#18 A Research Paper on the ROS-Mediated Induction of TGF-β1 by Male Hormones in Dermal Papilla Cells
Hyoseung Shin, Hyeon Gyeong Yoo, Shigeki Inni, Satoshi Itami, In Gyu Kim, A-Ri Cho, Dong Hun Lee, Won Seok Park, Ohsang Kwon, Kwang Hyun Cho, and Chong Hyun Won (2013) Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells. BMB Rep. 46(9): 460-464
In androgenetic alopecia (AGA), it is known that TGF-𝛃1, produced by dermal papilla cells (DPCs) in the hair loss scalp, is closely related to causing hair loss.
Researchers from Seoul National University Medical School have uncovered a critical link between androgen-induced reactive oxygen species (ROS) generation and TGF-β1 production in AGA pathogenesis.
Key Highlights:
Exposure of DPCs to the synthetic androgen methyltrienolone (r1881) triggered a significant increase in ROS generation.
ROS scavengers significantly suppress androgen-inducible TGF-β1 secretion.
Androgen-induced TGF-β1 expression is mediated by ROS signaling pathways.
