#3 Experimental Paper on Oxidative Stress-Related Aging in Dermal Papilla Cells of Androgenetic Alopecia
J.H. Upton, R.F. Hannen, A.W. Bahta, N.F. Farjo, B. Farjo and M.P. Philpott (2015) Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia. J. Invest. Dermatol. 135:1244-1252
This study delves into the impact of oxidative stress on dermal papilla cells (DPCs) in individuals with androgenetic alopecia (AGA), commonly known as male pattern hair loss.
The researchers demonstrate how oxidative stress triggers premature aging and the release of hair growth-inhibiting factors in these DPCs.
They meticulously examined the behavior of dermal papilla cells (DPCs), the crucial components of hair follicles, under varying oxygen concentrations.
Fig. 5 is considered the most crucial aspect of this paper.
Key Highlights:
Differential Response to Oxygen Levels: DPC from balding areas (BDPC) exhibited heightened sensitivity to oxidative stress compared to DPC from non-balding areas (ODPC).
Impact of partial pressure of oxygen: Both 21% oxygen (atmospheric oxygen) and 2% oxygen (physiological oxygen) exposure induced oxidative stress, but BDPC showed a stronger response, particularly under 21% oxygen.
Oxidative Stress-Induced Aging and Growth Inhibition: The researchers suggest that elevated oxidative stress in balding hair follicles leads to premature aging and reduced motility of DPC, contributing to hair loss.
