#4 Short Review: Impact of Acute Stress on Dermal Papilla Cells and Mast Cell Behavior
H. Shin, S.-J. Choi, A-R. Cho, D.Y. Kim, K.H. Kim, O. Kwon (2016) Acute Stress-Induced Changes in Follicular Dermal Papilla Cells and Mobilization of Mast Cells: Implications for Hair Growth. Ann. Dermatol. Vol. 28, No. 5, 600-606
It has long been speculated that stress may contribute to hair loss, and an intriguing experiment conducted by Seoul National University College of Medicine Dermatology Department in 2016 provided interesting findings. This research provides evidence that acute stress can negatively affect hair growth.
Key Highlights:
Stress-Induced DPC Growth Inhibition: Exposure to stress serum (obtained from stressed rats) significantly reduced DPC proliferation and prolonged the G1 phase of the cell cycle, indicating impaired hair growth.
Elevated Cortisol Levels: Stress serum exhibited a substantial increase in cortisol levels, suggesting a role of stress hormones in mediating these effects (Fig. 2).
Increased Mast Cell Number and Cytokine Expression: Acute stress led to a more than twofold increase in mast cell count and upregulation of tryptase, IL-6, IL-1β, IL-13, and TNF-α expression in mast cells (Fig. 3 and 4).
