#9 Research Paper on the Hair Growth Effects of Annurca Apple Extract
Gian Carlo Tenore, Domenico Caruso, Giuseppe Buonomo, Maria D’Avino, Rita Santamaria, Carlo Irace, Marialuisa Piccolo, Maria Maisto, and Ettore Novellino (2018) Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial. J. Med. Food 21(1) 90-103
This study investigated the hair growth-promoting effects of Annurca apple extract, a type of apple rich in oligomeric procyanidins, particularly procyanidin B2, found in abundance in Southern Italy.
However, a 2019 critical review of this study raised concerns regarding the clinical trial methodology (introduced in the next paper)
Key Highlights:
In vitro study: Annurca apple extract significantly promoted keratin protein expression in human skin cells.
Clinical trial: Participants receiving Annurca apple extract for two months exhibited a remarkable increase in hair growth, density, and keratin content compared to the control group.
