{"id":14777,"date":"2024-04-23T13:43:21","date_gmt":"2024-04-23T04:43:21","guid":{"rendered":"https:\/\/blmo.co.kr\/18-a-research-paper-on-the-ros-mediated-induction-of-tgf-%ce%b21-by-male-hormones-in-dermal-papilla-cells\/"},"modified":"2024-07-11T09:52:25","modified_gmt":"2024-07-11T00:52:25","slug":"18-a-research-paper-on-the-ros-mediated-induction-of-tgf-%ce%b21-by-male-hormones-in-dermal-papilla-cells","status":"publish","type":"post","link":"https:\/\/blmo.co.kr\/en\/18-a-research-paper-on-the-ros-mediated-induction-of-tgf-%ce%b21-by-male-hormones-in-dermal-papilla-cells\/","title":{"rendered":"#18 A Research Paper on the ROS-Mediated Induction of TGF-\u03b21 by Male Hormones in Dermal Papilla Cells"},"content":{"rendered":"\t\t
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Hyoseung Shin, Hyeon Gyeong Yoo, Shigeki Inni, Satoshi Itami, In Gyu Kim, A-Ri Cho, Dong Hun Lee, Won Seok Park, Ohsang Kwon, Kwang Hyun Cho, and Chong Hyun Won (2013) Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells. BMB Rep. 46(9): 460-464<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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In androgenetic alopecia (AGA), it is known that TGF-\ud835\udec31, produced by dermal papilla cells (DPCs) in the hair loss scalp, is closely related to causing hair loss.<\/p>\n

Researchers from Seoul National University Medical School have uncovered a critical link between androgen-induced reactive oxygen species (ROS) generation and TGF-\u03b21 production in AGA pathogenesis.<\/p>\n

 <\/p>\n

Key Highlights:<\/p>\n

Exposure of DPCs to the synthetic androgen methyltrienolone (r1881) triggered a significant increase in ROS generation.<\/p>\n

ROS scavengers significantly suppress androgen-inducible TGF-\u03b21 secretion.<\/p>\n

Androgen-induced TGF-\u03b21 expression is mediated by ROS signaling pathways.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Hyoseung Shin, Hyeon Gyeong Yoo, Shigeki Inni, Satoshi Itami, In Gyu Kim, A-Ri Cho, Dong Hun Lee, Won Seok Park, Ohsang Kwon, Kwang Hyun Cho, and Chong Hyun Won (2013) Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells. BMB Rep. 46(9): 460-464 In […]<\/p>\n","protected":false},"author":1,"featured_media":14572,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[64],"tags":[],"class_list":["post-14777","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-papers-on-hair-loss"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts\/14777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/comments?post=14777"}],"version-history":[{"count":2,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts\/14777\/revisions"}],"predecessor-version":[{"id":15705,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts\/14777\/revisions\/15705"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/media\/14572"}],"wp:attachment":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/media?parent=14777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/categories?post=14777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/tags?post=14777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}