{"id":14777,"date":"2024-04-23T13:43:21","date_gmt":"2024-04-23T04:43:21","guid":{"rendered":"https:\/\/blmo.co.kr\/18-a-research-paper-on-the-ros-mediated-induction-of-tgf-%ce%b21-by-male-hormones-in-dermal-papilla-cells\/"},"modified":"2024-07-11T09:52:25","modified_gmt":"2024-07-11T00:52:25","slug":"18-a-research-paper-on-the-ros-mediated-induction-of-tgf-%ce%b21-by-male-hormones-in-dermal-papilla-cells","status":"publish","type":"post","link":"https:\/\/blmo.co.kr\/en\/18-a-research-paper-on-the-ros-mediated-induction-of-tgf-%ce%b21-by-male-hormones-in-dermal-papilla-cells\/","title":{"rendered":"#18 A Research Paper on the ROS-Mediated Induction of TGF-\u03b21 by Male Hormones in Dermal Papilla Cells"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"14777\" class=\"elementor elementor-14777 elementor-14570\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-27840c92 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"27840c92\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-348ca2d1\" data-id=\"348ca2d1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1b7bb3d2 elementor-widget elementor-widget-text-editor\" data-id=\"1b7bb3d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Hyoseung Shin, Hyeon Gyeong Yoo, Shigeki Inni, Satoshi Itami, In Gyu Kim, A-Ri Cho, Dong Hun Lee, Won Seok Park, Ohsang Kwon, Kwang Hyun Cho, and Chong Hyun Won (2013) Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells. BMB Rep. 46(9): 460-464<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6ed22b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6ed22b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-94ae866\" data-id=\"94ae866\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c0be36c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c0be36c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-80ecdae\" data-id=\"80ecdae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ca73f71 elementor-widget elementor-widget-image\" data-id=\"ca73f71\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.google.com\/search?q=Hyoseung+Shin%2C+Hyeon+Gyeong+Yoo%2C+Shigeki+Inni%2C+Satoshi+Itami%2C+In+Gyu+Kim%2C+A-Ri+Cho%2C+Dong+Hun+Lee%2C+Won+Seok+Park%2C+Ohsang+Kwon%2C+Kwang+Hyun+Cho%2C+and+Chong+Hyun+Won+(2013)+Induction+of+transforming+growth+factor-beta+1+by+androgen+is+mediated+by+reactive+oxygen+species+in+hair+follicle+dermal+papilla+cells.&#038;oq=Hyoseung+Shin%2C+Hyeon+Gyeong+Yoo%2C+Shigeki+Inni%2C+Satoshi+Itami%2C+In+Gyu+Kim%2C+A-Ri+Cho%2C+Dong+Hun+Lee%2C+Won+Seok+Park%2C+Ohsang+Kwon%2C+Kwang+Hyun+Cho%2C+and+Chong+Hyun+Won+(2013)+Induction+of+transforming+growth+factor-beta+1+by+androgen+is+mediated+by+reactive+oxygen+species+in+hair+follicle+dermal+papilla+cells.&#038;gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIGCAEQRRg70gEINjE5ajBqMTWoAgiwAgE&#038;sourceid=chrome&#038;ie=UTF-8\" target=\"_blank\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"508\" height=\"722\" src=\"https:\/\/blmo.co.kr\/wp-content\/uploads\/2024\/04\/18\ubc88\uc378\ub124\uc77c-e1720659139900.png\" class=\"attachment-medium_large size-medium_large wp-image-14572\" alt=\"\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-64b756f\" data-id=\"64b756f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8bfe23b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"8bfe23b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In androgenetic alopecia (AGA), it is known that TGF-\ud835\udec31, produced by dermal papilla cells (DPCs) in the hair loss scalp, is closely related to causing hair loss.<\/p>\n<p>Researchers from Seoul National University Medical School have uncovered a critical link between androgen-induced reactive oxygen species (ROS) generation and TGF-\u03b21 production in AGA pathogenesis.<\/p>\n<p>&nbsp;<\/p>\n<p>Key Highlights:<\/p>\n<p>Exposure of DPCs to the synthetic androgen methyltrienolone (r1881) triggered a significant increase in ROS generation.<\/p>\n<p>ROS scavengers significantly suppress androgen-inducible TGF-\u03b21 secretion.<\/p>\n<p>Androgen-induced TGF-\u03b21 expression is mediated by ROS signaling pathways.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-48f87d5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"48f87d5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c731983\" data-id=\"c731983\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9623424 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9623424\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ae2ff12\" data-id=\"ae2ff12\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fa7cb6c elementor-widget elementor-widget-spacer\" data-id=\"fa7cb6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hyoseung Shin, Hyeon Gyeong Yoo, Shigeki Inni, Satoshi Itami, In Gyu Kim, A-Ri Cho, Dong Hun Lee, Won Seok Park, Ohsang Kwon, Kwang Hyun Cho, and Chong Hyun Won (2013) Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells. BMB Rep. 46(9): 460-464 In [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14572,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[64],"tags":[],"class_list":["post-14777","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-papers-on-hair-loss"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Hyoseung Shin, Hyeon Gyeong Yoo, Shigeki Inni, Satoshi Itami, In Gyu Kim, A-Ri Cho, Dong Hun Lee, Won Seok Park, Ohsang Kwon, Kwang Hyun Cho, and Chong Hyun Won (2013) Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells. 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