{"id":14779,"date":"2024-04-23T13:59:03","date_gmt":"2024-04-23T04:59:03","guid":{"rendered":"https:\/\/blmo.co.kr\/19-a-research-paper-on-suppression-of-keratinocyte-growth-by-androgen-induced-tgf-%ce%b21-from-dermal-papilla-cells\/"},"modified":"2024-05-14T10:02:33","modified_gmt":"2024-05-14T01:02:33","slug":"19-a-research-paper-on-suppression-of-keratinocyte-growth-by-androgen-induced-tgf-%ce%b21-from-dermal-papilla-cells","status":"publish","type":"post","link":"https:\/\/blmo.co.kr\/en\/19-a-research-paper-on-suppression-of-keratinocyte-growth-by-androgen-induced-tgf-%ce%b21-from-dermal-papilla-cells\/","title":{"rendered":"#19 A Research Paper on Suppression of Keratinocyte Growth by Androgen-Induced TGF-\u03b21 from Dermal Papilla Cells"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Shigeki Inui, Yoko Fukuzato, Takeshi Nakajima, Kunihiko Yoshikawa, and Satoshi Itami (2002) Androgen-inducible TGF-\ud835\udec31 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth. The FASEB J. V16, Issue 14, 1853e.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"18\ubc88\uc378\ub124\uc77c\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

This study demonstrates that TGF-\u03b21 produced by dermal papilla cells (DPCs) in alopecia patients inhibits the growth of epithelial cells (keratinocytes). This was shown using a co-culture system where human DPCs with androgen receptor gene expression vectors were co-cultured with keratinocytes and exposed to androgen. Androgen treatment resulted in approximately 50% suppression of keratinocyte growth. Further analysis revealed that TGF-\u03b21 was the signaling molecule responsible for this effect. These findings suggest that androgen-induced TGF-\u03b21 from DPCs plays a crucial role in suppressing keratinocyte growth and contributing to alopecia.<\/p>\n

 <\/p>\n

Key Highlights:<\/p>\n

Androgen exposure to DPC cells in a co-culture system with keratinocytes significantly suppressed keratinocyte growth.<\/p>\n

TGF-\u03b21 neutralization abolished the androgen-induced suppression of keratinocyte growth, confirming the role of TGF-\u03b21.<\/p>\n

The mechanism of androgen-induced TGF-\u03b21 production in DPCs remains to be investigated.<\/p>\n

 <\/p>\n

Connection to Previous Study (#18)<\/p>\n

The findings of this study align with those of the previous study (#18), which suggested that reactive oxygen species (ROS) mediate androgen-induced TGF-\u03b21 production in DPCs. This suggests that ROS may play an upstream role in the TGF-\u03b21-mediated suppression of keratinocyte growth observed in alopecia patients.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Shigeki Inui, Yoko Fukuzato, Takeshi Nakajima, Kunihiko Yoshikawa, and Satoshi Itami (2002) Androgen-inducible TGF-\ud835\udec31 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth. The FASEB J. V16, Issue 14, 1853e. This study demonstrates that TGF-\u03b21 produced by dermal papilla cells (DPCs) in alopecia […]<\/p>\n","protected":false},"author":1,"featured_media":14584,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[64],"tags":[],"class_list":["post-14779","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-papers-on-hair-loss"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts\/14779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/comments?post=14779"}],"version-history":[{"count":1,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts\/14779\/revisions"}],"predecessor-version":[{"id":14780,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts\/14779\/revisions\/14780"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/media\/14584"}],"wp:attachment":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/media?parent=14779"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/categories?post=14779"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/tags?post=14779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}