{"id":14781,"date":"2024-04-23T14:21:38","date_gmt":"2024-04-23T05:21:38","guid":{"rendered":"https:\/\/blmo.co.kr\/20-a-research-paper-on-dermal-adipose-tissue-and-hair-growth-pigmentation-unveiling-the-role-of-hepatocyte-growth-factor\/"},"modified":"2024-05-14T10:03:04","modified_gmt":"2024-05-14T01:03:04","slug":"20-a-research-paper-on-dermal-adipose-tissue-and-hair-growth-pigmentation-unveiling-the-role-of-hepatocyte-growth-factor","status":"publish","type":"post","link":"https:\/\/blmo.co.kr\/en\/20-a-research-paper-on-dermal-adipose-tissue-and-hair-growth-pigmentation-unveiling-the-role-of-hepatocyte-growth-factor\/","title":{"rendered":"#20 A Research Paper on Dermal Adipose Tissue and Hair Growth\/Pigmentation: Unveiling the Role of Hepatocyte Growth Factor"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"14781\" class=\"elementor elementor-14781 elementor-14594\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-27840c92 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"27840c92\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-348ca2d1\" data-id=\"348ca2d1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1b7bb3d2 elementor-widget elementor-widget-text-editor\" data-id=\"1b7bb3d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Carina Nicu, James D.B. O\u2019Sullivan, Raul Ramos, Ludovica Timperi, Tiffany Lai, Nilofer Farjo, Bessam Farjo, Jenny Pople, Ranjit Bhogal, Jonathan A. Hardman, Maksim V. Plikus, David M. Ansell and Ralf Paus (2021) Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation. J. Invest. Dermatol. 141, 1633-1645.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6ed22b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6ed22b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-94ae866\" data-id=\"94ae866\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c0be36c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c0be36c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-80ecdae\" data-id=\"80ecdae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ca73f71 elementor-widget elementor-widget-image\" data-id=\"ca73f71\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33493531\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"211\" height=\"300\" src=\"https:\/\/blmo.co.kr\/wp-content\/uploads\/2024\/04\/18\ubc88\uc378\ub124\uc77c-211x300.png\" class=\"attachment-medium size-medium wp-image-14572\" alt=\"\" srcset=\"https:\/\/blmo.co.kr\/wp-content\/uploads\/2024\/04\/18\ubc88\uc378\ub124\uc77c-211x300.png 211w, https:\/\/blmo.co.kr\/wp-content\/uploads\/2024\/04\/18\ubc88\uc378\ub124\uc77c.png 508w\" sizes=\"(max-width: 211px) 100vw, 211px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-64b756f\" data-id=\"64b756f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8bfe23b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"8bfe23b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>This study delves into the intricate relationship between dermal adipose tissue (dWAT) and human hair growth and pigmentation. It sheds light on how dWAT surrounding hair follicles (HFs) influences these processes through a signaling molecule called Hepatocyte Growth Factor (HGF).<\/p>\n<p>&nbsp;<\/p>\n<p>Key Highlights:<\/p>\n<p>The size and fat-burning activity of dWAT cells change throughout the hair growth cycle, suggesting their involvement in hair development.<\/p>\n<p>dWAT promotes hair growth by stimulating hair shaft production and keratinocyte proliferation in the hair matrix.<\/p>\n<p>dWAT also enhances hair pigmentation by promoting the differentiation of melanin-producing cells.<\/p>\n<p>Pericytes and progenitor cells within dWAT secrete HGF, which interacts with the c-Met receptor in the hair follicle.<\/p>\n<p>HGF treatment mimics the effects of dWAT on hair growth and pigmentation, while blocking HGF signaling negates these effects.<\/p>\n<p>HGF activates the Wnt\/\u03b2-catenin pathway, a critical pathway for hair growth.<\/p>\n<p>HGF from dWAT regulates the expression of genes essential for hair structure and color (keratin genes and TCHH).<\/p>\n<p>Figure 6 provides a schematic overview of the researchers&#8217; proposed mechanism<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-48f87d5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"48f87d5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c731983\" data-id=\"c731983\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9623424 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9623424\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ae2ff12\" data-id=\"ae2ff12\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fa7cb6c elementor-widget elementor-widget-spacer\" data-id=\"fa7cb6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Carina Nicu, James D.B. O\u2019Sullivan, Raul Ramos, Ludovica Timperi, Tiffany Lai, Nilofer Farjo, Bessam Farjo, Jenny Pople, Ranjit Bhogal, Jonathan A. Hardman, Maksim V. Plikus, David M. Ansell and Ralf Paus (2021) Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation. J. Invest. Dermatol. 141, 1633-1645. This study delves into the intricate [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14596,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[64],"tags":[],"class_list":["post-14781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-papers-on-hair-loss"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Carina Nicu, James D.B. 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