{"id":16772,"date":"2025-10-30T16:29:35","date_gmt":"2025-10-30T07:29:35","guid":{"rendered":"https:\/\/blmo.co.kr\/?p=16772"},"modified":"2025-10-30T16:39:00","modified_gmt":"2025-10-30T07:39:00","slug":"25-intermittent-fasting-triggers-interorgan-communication-to-suppress-hair-follicle-regeneration","status":"publish","type":"post","link":"https:\/\/blmo.co.kr\/en\/25-intermittent-fasting-triggers-interorgan-communication-to-suppress-hair-follicle-regeneration\/","title":{"rendered":"#26 5-Fluorouracil induces hair loss by inhibiting \u03b2-catenin signaling and angiogenesis"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Jung-Il Kang, Youn Kyung Choi, Sang-Chul Han, Jin Won Hyun, Young-Sang Koh, Jaeseong Oh, Hye-Jin Boo, Eun-Sook Yoo, Hee-Kyoung Kang<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

This research paper aims to investigate the effects of 5-fluorouracil (5-FU), a component of chemotherapy drugs, on dermal papilla (DP) cells and to elucidate the mechanism by which it induces hair loss through regulation of Wnt\/\u03b2-catenin signaling, angiogenesis, and the expression of growth factors. Although 5-FU generally causes less hair loss compared to other anticancer drugs, its exact mechanism of action has not been clearly understood.<\/p>\n

 <\/p>\n

The research team analyzed the effects of 5-FU using both mouse models and cell experiments. The results showed that 5-FU delays the transition of the hair cycle into the anagen (growth) phase and inhibits angiogenesis around the hair follicles. This suggests that reduced blood supply hinders hair growth.<\/p>\n

 <\/p>\n

At the cellular level, 5-FU induced cell cycle arrest and apoptosis in dermal papilla cells. Notably, it suppressed the Wnt\/\u03b2-catenin signaling pathway, a crucial signaling system that regulates hair growth and the hair cycle. Additionally, the expression of vascular endothelial growth factor (VEGF) and its receptor Flk-1 was reduced, indicating a diminished capacity for blood vessel formation.<\/p>\n

 <\/p>\n

In summary, 5-FU induces hair loss by disrupting the cells and signaling pathways involved in hair growth, as well as by impairing angiogenesis. Previously, chemotherapy-induced hair loss was mainly considered a problem of epidermal cells. However, this study revealed that 5-FU also has a fatal impact on dermal papilla cells, a deeper structure within the hair follicle.<\/p>\n

 <\/p>\n

These findings could provide an important foundation for developing treatments for hair loss in patients undergoing chemotherapy with 5-FU.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Jung-Il Kang, Youn Kyung Choi, Sang-Chul Han, Jin Won Hyun, Young-Sang Koh, Jaeseong Oh, Hye-Jin Boo, Eun-Sook Yoo, Hee-Kyoung Kang This research paper aims to investigate the effects of 5-fluorouracil (5-FU), a component of chemotherapy drugs, on dermal papilla (DP) cells and to elucidate the mechanism by which it induces hair loss through regulation of […]<\/p>\n","protected":false},"author":1,"featured_media":16775,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[64],"tags":[],"class_list":["post-16772","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-papers-on-hair-loss"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts\/16772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/comments?post=16772"}],"version-history":[{"count":3,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts\/16772\/revisions"}],"predecessor-version":[{"id":16781,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/posts\/16772\/revisions\/16781"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/media\/16775"}],"wp:attachment":[{"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/media?parent=16772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/categories?post=16772"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blmo.co.kr\/en\/wp-json\/wp\/v2\/tags?post=16772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}